Animal ⇄ Human Dose Converter
FDA-compliant allometric scaling with dynamic Km adjustment, biologics mode, POD selector (NOAEL/HNSTD/MABEL), and reverse human→animal calculator.
Conversion Results
Formula Applied
Dose Schedule (Daily)
| Frequency | HED per dose (mg/kg) | Total daily (mg/kg) | 60 kg human (mg) | MRSD (mg/kg) |
|---|
Cross-Species Comparison
📋 Regulatory Context
- HED is used to set the Maximum Recommended Starting Dose (MRSD) for Phase I trials
- FDA recommends dividing HED by safety factor (typically 10×) → MRSD
- For oncology (ICH S9): use HNSTD with 1/6 safety factor for non-rodents
- MABEL is most conservative — used for high-risk or novel biologics
- For biologics (>100 kDa), FDA recommends 1:1 weight-based normalization (mg/kg), not BSA
Looking to convert a Human Dose to an Animal Dose instead?
While the interactive computational tool above is hardcoded to convert animal dose to human dose with FDA compliance pathing, you can easily execute the reverse calculation.To convert a human clinical dose back to an animal model, use the pre-calculated Inverse Multiplier Factor from our master reference table below:
Animal Dose (mg/kg) = Human Dose (mg/kg) × Inverse Multiplier Factor
Example: To scale a 5 mg/kg human dose down to a Rat model, find Rat in the table, locate its multiplier (6.17), and calculate: 5 × 6.17 = 30.85 mg/kg.
FDA Allometric Scaling Reference Standards (Km Values)
| Species | Ref. Weight (kg) | Standard Km Factor | Inverse Multiplier Factor (Human to Animal: 37 / Km) |
|---|---|---|---|
| Human (Adult Baseline) | 60.0 kg | 37 | 1.00 (Base) |
| Dog | 10.0 kg | 20 | 1.85 |
| Monkey (Rhesus) | 3.0 kg | 12 | 3.08 |
| Rabbit | 1.8 kg | 12 | 3.08 |
| Rat | 0.15 kg | 6 | 6.17 |
| Guinea Pig | 0.40 kg | 8 | 4.63 |
| Hamster | 0.08 kg | 5 | 7.40 |
| Mouse | 0.02 kg | 3 | 12.33 |
Key Formulas Used by the Validation Engine
Standard Human Equivalent Dose (HED) Formula:
HED (mg/kg) = Animal Dose (mg/kg) x Animal Km / Human Km
Dynamic Weight-Adjusted Allometric Formula: If a researcher overrides the standard reference animal weight in the input field, the calculator dynamically scales the baseline Km factor using the 0.33 power scaling law before processing the HED:
Adjusted Km = Reference Km x (Actual Weight/Reference Weight)0.33
Preclinical Scaling & Computational Software
In translational drug discovery, moving from in vivo animal models to initial human trials requires strict regulatory compliance. While historically researchers relied on static, manual calculation sheets, modern laboratory environments require cloud-based validation tools to rapidly execute complex body surface area (BSA) equations without the risk of human mathematical error.
Software for animal to human dose conversion?
Most commercial pharmacokinetic (PK) modeling software programs cost thousands of dollars per seat license. Our Advanced FDA Dose Extrapolator provides an accessible, browser-based alternative built explicitly on the FDA Guidelines for Industry. It functions as a complete software-as-a-service (SaaS) tool that requires no complex local desktop installation, enabling research teams to collaborate on scaling parameters across cloud networks smoothly.
What are the best online tools for Animal to Human Dose Extrapolator systems?
The best computational web utilities must go beyond basic multiplication. When evaluating online tools for preclinical translational math, ensure the platform supports:
- Dynamic Allometric Adjustment: Real-time recalculation of the baseline Km factor if your test subject’s weight deviates from standard reference weights.
- Biologics Exceptions Mode: Automatic override options to enforce a 1:1 weight normalization matrix for high molecular weight compounds (>100 kDa).
- Multi-POD Threshold Adjustments: The structural capacity to evaluate NOAEL, HNSTD, or MABEL starting parameters interchangeably.
Where to buy professional animal-to-human dose conversion services?
If your research laboratory or biotech firm is preparing an Investigational New Drug (IND) application, hiring third-party contract research organizations (CROs) for simple dose translation services can cost thousands in consulting fees. Our Premium Pharmacology Suite provides a direct, cost-effective alternative for computational verification. It allows you to process unlimited compliant scaling operations instantly, generating transparent regulatory verification traces perfect for internal auditing and methodology draft compilation.