Pancreatic Enzymes| List and their Function in the digestion

The pancreas is one of the important glands in our body. The pancreatic enzymes include

1. Amylase

2. Trypsin

3. Chymotrypsin

4. Carboxypolypeptidases

5. Lipase

6. Phospholipase A2

7. Lysophospholipase or phospholipase B

8. Cholesterol esterase.

9. Nucleases.

Pancrease is a left side organ located just below the stomach opening into the duodenum. Its secretion directly enters the duodenum of the intestine.

It is a dual type of gland, i.e., unlike other glands it has both exocrine and endocrine functions.

The endocrine gland part of pancreas secretes hormones like insulin, glucagon, etc.

While the exocrine part of it secretes enzymes through the pancreatic duct.

Pancreatic enzymes:

Pancreatic secretion contains enzymes and also large amounts of bicarbonates. These bicarbonates help to neutralize the acid chyme coming from the stomach into the duodenum.

Amylase: Is the enzyme which breaks down carbohydrates like sucrose, fructose, and starch. The end product of this breakdown is glucose which is easily absorbed by the gut.

Trypsin & Chymotrypsin: Both these enzymes are inactive as such. But are activated by enterokinase from microvilli. They help in breaks down proteins from food into polypeptides, tripeptides, etc.

Carboxypolypeptidases: The peptides formed due to trypsin and chymotrypsin are digested by this enzyme. This carboxypolypeptidases convert peptides into individual amino acids. These amino acids are easily absorbed into the blood from the gut.

Lipase: Helps in the breakdown of lipids and fats into fatty acids and glycerols for easy absorption.

Phospholipase: They help in the breakdown of cell membranes into arachidonic acids.

Phospholipase B: This enzyme cleaves acyl portions of the phospholipids.

Cholesterol esterase: This enzyme catalyzes the cholesterol esters to unesterified cholesterol and free fatty acids.

Nucleases: These enzymes as the name indicates are meant for digestion of nucleotide molecule of DNA and RNA.

Trypsin inhibitor: This is the panacreatic secretion which inhibits the activation of the enzyme trypsin inside the pancreas. If trypsin is activated before it is secreted, it would lead to digestion of pancreas itself. Hence, this trypsin inhibitor saves pancreas from the digestive action of these proteolytic enzymes.

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