Biochemistry is the study of biological molecules and their reactions in the body physiology.
The study of biochemistry is important for doctors, nurses, pharmacists, allied heath care individuals and biology students.
It is used in clinical diagnosis, manufacture of various biological products, treatment of diseases, in nutrition, agriculture, etc.
That is it is concerned about the internal chemistry of biological systems of animals and plants.
Since it is so vast and new phenomenon are discovered every year, it is taught as a separate branch of biology.
One can study biochemistry as a part of graduation or post graduation like in medical biochemistry, forensic biochemistry, agriculture biochemistry, etc.
It describes their origin, formation, function, deficiency symptoms, etc. It tries to explain life in terms of biochemical reactions. One can understand all the chemical reactions happening at the molecular level in a living cell or living being. The role of biochemistry and its importance in various fields is as described below.
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Importance of biochemistry in MEDICINE
Biochemistry is a valuable subject in medicine without which there would have been no such advancement in the field.
- Physiology: Biochemistry helps one understand the biochemical changes and related physiological alteration in the body. Pathology of any disease is studied through biochemical changes.
- Pathology: Based on the symptoms described by the patient, the physician can get a clue on the biochemical change and the associated disorder. For example, if a patient complains about stiffness in small joints, then the physician may predict it to be gout and get confirmed by evaluating uric acid levels in the blood as uric acid accumulation in blood results in gout.
- Nutrition deficiency: In the present scenario, many people rely on taking multivitamin & minerals for better health. The function and role of the vitamin in the body are described only by biochemistry.
- Hormonal deficiency: There are many disorders due to hormonal imbalance in especially women and children. The formation, role of hormones in the normal body function is taught in biochemistry by which the physician can understand the concerned problem during treatment.
Importance of biochemistry in NURSING
In nursing, the importance of clinical biochemistry is invaluable. When a patient is in the hospital nurses, need to keep a watch on how his condition is progressing through clinical biochemistry. That is the treatment for helping him recover from said condition etc. Almost all diseases or disorders have some biochemical involvement. So the diagnosis of any clinical condition is easily possible by biochemical estimations.
- Kidney function test: For example in kidney disorders, other chemotherapy treatment, etc. urine test help understand the extent of excretion of drugs or other metabolites, the change in pH, the color of urine, etc.
- Blood test: In diabetes, biochemical analytical test for blood glucose level (above 150mg/deciliter) helps one understand the severity of diabetes disorder. Another biochemical analysis for ketones bodies in urine also indicates the stage of diabetes. The appearance of ketone bodies or ketone urea is mostly the last stage of diabetes.
- Liver function tests help understand the type of disease or damage to the liver, the effect of any medication on the liver, etc.
- Serum cholesterol test: Evaluation of blood cholesterol level and other lipoproteins helps to understand the proneness of the patient to cardiovascular diseases.
Thus the importance of clinical biochemistry is to help the nurse monitor the patient’s condition regularly during the treatment.
Importance of biochemistry in AGRICULTURE
In agriculture, biochemistry plays a valuable role in farming, fishery, poultry, sericulture, beekeeping, etc.
- Prevent diseases: It helps for prevention, treatment of diseases and also increases the production or yield.
- Enhance growth: Biochemistry gives an idea of how the use of fertilizers can increase plant growth, their yield, quality of food, etc.
- Enhance Yield: Some hormones promote growth, while others encourage flowering, fruit formation, etc. In fisheries, the use of substances to promote fish growth, their reproduction, etc. can be understood.
- Adulteration: Even the composition of food material produced, their alteration or adulteration for example in honey can be found by biochemical tests. Biochemistry tests help prevent contamination.
- Biochemical tests for the pesticide residues or other toxic waste in plant, food grain and soil can be evaluated. Hence during import and export of food grains, a biochemical check of the toxic residues is done to fix the quality.
- In animal husbandry, the quality of milk can be checked by biochemical tests. It also helps diagnose any disease condition in animals and birds.
- In fisheries, the water quality is regularly monitored by biochemical tests. Any drastic change in water chemistry & composition of fishery ponds can lead to the vast death of fishes and prawns. Hence the tests are done regularly to see salt content (calcium content), pH, accumulation of waste due to not changing water for long, etc.
Importance of biochemistry in NUTRITION
In nutrition, biochemistry describes food chemistry. For maintenance of health, optimum intake of many biochemicals like macro, micronutrients, vitamins, minerals, essential fatty acids & water is necessary.
- Food chemistry gives an idea of what we eat, i.e., it’ s components like carbohydrates, proteins, fats, etc. and also the possible physiological alteration due to their deficiency.
- The role of nutrients: Due to biochemistry the importance of vitamins, minerals, essential fatty acids, their contribution to health were known. Hence there is a frequent recommendation for inclusion of crucial amino-acids, cod liver oil, salmon fish oil, etc. by physicians and other health and fitness experts.
- The nutrients value of food material can also be determined by biochemical tests.
- The physician can prescribe to limit usage of certain food like excess sugar for diabetics, excess oil for heart & lung problem prone patients, etc. As these carbohydrate and fat diets can inhibit the recovery rate from said disorder. This knowledge is due to their idea of food chemistry and related
Importance of biochemistry in PHARMACY
In a pharmacy, many drugs are stored for regular dispensing.
- Drug Constitution: Biochemistry gives an idea of the constitution of the drug, its chances of degradation with varying temperature, etc. How modification in medicinal chemistry helps improve efficiency, minimize side effects, etc.
- The half-life: This is a test done on biochemical drugs to know how long a drug is stable when kept at so and so temperature.
- Drug storage: The storage condition required can be estimated by the biochemical test. For example many enzymes, hormones are stored for dispensing. These get deteriorated over time due to temperature or oxidation, contamination and also due to improper storage.
- Drug metabolism: It also gives an idea of how drug molecules are metabolized by many biochemical reactions in the presence of enzymes. This helps to avoid drugs which have a poor metabolism or those with excessive side effects from being prescribed or dispensed to the patient.
- Biochemical tests: These tests help fix the specific half-life or date of expiry of drugs.
Importance of biochemistry in plants
Biochemistry of plants gave way to the breakthrough of how food is synthesized in them and the reason why they are autotrophs, i.e., not dependent on other living beings for food. Biochemistry in plants describes
1. Photosynthesis: This describes how carbohydrates are synthesized by the use of sunlight, CO2, and water in the green leaves of plants. It goes on to explain about different complex enzymes involved in the process to combine the energy of sun within the molecules H2O+ CO2 in the form of carbohydrates.
2. Respiration: By use of the above photosynthesis pathway, plants leave out Oxygen while taking up Carbon dioxide from the air. This air is used to generate energy in a cell like that of animal cells.
3. Different sugars: Biochemistry defines different types of carbohydrates formed in plants like trioses (3 carbon sugars, i.e., glyceraldehyde), tetroses (4), pentoses (5), hexoses (6= glucose), heptoses (7), etc. Tetroses are the carbohydrates which go on to form the nucleic acids, i.e., deoxyribonucleic acid (DNA), ribonucleic acid (RNA).
4. Plants secondary metabolites: Biochemistry also describes how the plant products like gums, tannins, alkaloids, resins, enzymes, phytohormones are formed inside the plant. Further, how the different plant cell parts are involved in physiology. The conversion of different biochemical over some time like lignin, chitin to harden the dead vascular vessels, etc.
5. Other functions: It also describes how plants fruits get ripened, how to plant seed germinates, the respiration process inside the plant cell, how proteins and amino acids are formed on rough endoplasmic reticulum and fats are formed on smooth ER.
References: Lehninger Principles of Biochemistry
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