Streptococcus vs Staphylococcus | 20 Key Differences

Streptococcus and Staphylococcus bacteria are widely found in humans and animals. They are non-motile, do not undergo spore formation, and are even facultative anaerobes.

Streptococcus vs StaphylococcusBut there are many differences between Streptococcus vs Staphylococcus bacteria as seen in the table below.

Streptococcus vs Staphylococcus

1Bacteria typeStreptococcus is a Gram-positive bacteria, forming a short-chain.Staphylococcus is also a gram-positive bacteria, but it forms
cluster shape.
2Taxonomical ClassificationClass: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
3Cell ArrangementThe Streptococcus cells are arranged by single-chain containing spherical cells.The Staphylococcus cells are arranged in grapes, like clusters,
also present in tetrads, short chains.
4Site of infection in humans and animalsThe habitat of Streptococcus
in animals is the respiratory
tract and mouth.
The habitat of Staphylococcus
in animals is the skin and other outer
5MultiplicationThe multiplication of the streptococcus by binary fission is in a linear way along a single axis only.While the multiplication of the
Staphylococcus by binary fission occurs in multiple ways due to various axes.
6Number of
Approximately 50 different types of Streptococcal species
are identified.
Nearly 40 different species of
Staphylococcal species are identified.
7PathogenesisMost of the Streptococcal
species are pathogenic.
Some of the Staphylococci
species are pathogenic.
8Growth MediaStreptococcus bacteria require enriched media to
The Staphylococcus does not need enriched media to grow.
Most of the streptococcus
species are facultative
anaerobes, but some of them are obligate anaerobes.
Most of the Staphylococcus
species are aerobes, but some of them are facultative anaerobes.
10FastidiousThe Streptococcus organisms are fastidious i.e. require special nutrients or conditions.The Staphylococcus organisms are not fastidious.
11PigmentsThe Streptococcus
organisms do not produce any pigments while growing in the
Staphylococcus organisms do produce the golden-yellow colored pigment while growing in the media.
12Infectious Discharge typeSerous discharge is produced by the Streptococcus organism to cause an infection, because of enzyme StreptodornasePurulent discharge is the type produced by the Staphylococcus
organisms to cause an infection
13Hemolysis typeEither Alpha, Beta, or Gamma
hemolysis occurs.
1) Alpha Hemolysis: The colony appears as a dark and greenish color.
2) Beta Hemolysis: The colony appears as lightened yellow color.
3) Gamma Hemolysis:
The colony undergoes
No hemolysis or sometimes Beta hemolysis occurs.
14GenomeThe genome sizes of the Streptococcus are 1.8 to 2.3 Mb, and encoded1, 700 to 2,300 proteins.The Genome sizes of the Staphylococcus are 1 to 2.5 Mb.
15BacteriophagesThe Streptococcus organisms are susceptible to
The Staphylococcus organisms are not susceptible to the
16ToxinThey cannot produce the toxins but they can cause
severe infections.
The Staphylococcus are able to produce the toxins to cause
some infections in humans.
17Group classificationThe Streptococcus organism
is divided into 7 groups,
1) Group A: S.pyogenes
2) Group B: S.agalactiae
3) Group C: S.equi
4) Group D: S. faecalis
5) Group F: S. anginosus
6) Group G: S. canis
7) Group H: S. bovis
The Staphylococcus organisms
are divided into 3 groups,
1) Group A: S.aureus
2) Group B: S. arlettae
3) Group C: S. delphini
18Catalase productionStreptococcus organisms cannot produce the catalase enzyme, so the negative results occur in the catalase
Staphylococcus organisms produce the catalase enzyme; it gives positive results for the catalase test.
The most pathogenic species are Streptococcus pneumonia, Streptococcus pyogenes, Streptococcus agalactiae.The most pathogenic species are
Staphylococcus aureus and Staphylococcus saprophyticus.
20Biochemical TestTo identify the streptococcus
species, the tests like the Catalase test, Bile solubility test, Bacitracin Sensitivity test, CAMP Test, Optochin
Sensitivity Test is used.
To identify the Staphylococcus
species, the tests like the Catalase test, Novobiocin Sensitivity test, and coagulase test are used.
21Diseases causedThe common diseases caused
by the streptococcus
organisms are strep throat, scarlet fever, toxic shock syndrome, blood infections, meningitis, pneumonia,
cellulitis, Necrotizing
The Common disease caused by the Staphylococcal organisms are Food poisoning, surgical site infection, wound infection, bacterial conjunctivitis, skin disease, community-acquired meningitis
22Treatment/ vaccine (prevention)Streptococcal infections can
be cured or prevented by penicillin.
The staphylococcal infection
can be cured or prevented by the vancomycin.

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