T lymphocytes and B lymphocytes are both white blood cells involved in the fight against infections in our bodies.
They provide immunity and also help to prevent future infections.
Differences between T cells and B cells
|Sl.No||Characteristics||T Cells||B Cells|
|1||Alternative names||They are also called T|
|They are also called as B Lymphocytes|
|2||Role in Immunity||T Cell is responsible for the development of cellular and humoral immunity (T Cell activates B- cells)||B Cell helps in the development of humoral immunity|
|3||Source or Origin||T Cells formed in the bone marrow. But they get matured in the Thymus gland.||Whereas B cells originate and also|
get matured in the bone marrow
|4||Mature cells||Mature cells occur inside the lymph nodes.||Mature cells occur outside the lymph nodes.|
|5||Processing||T cell processing occurs mostly during the period between just before birth and a few months after birth.||B cell processing in mammals takes|
place in the liver (during fetal life)
and bone marrow (after birth).
|6||Discovery||T Cells were found during the ingestion of the foreign particles in the body.||B lymphocytes were discovered in|
the Bursa of Fabricius (lymphoid
organ situated near the cloacae of
birds) in birds, hence the name B
|7||Mobility||T Cells are highly motile.||B Cells are less motile.|
|These receptors are absent in the T Cells.||The complement receptors are|
present in the B Cells.
|T Cell only bears TCR receptors||B Cells only bear BCR receptors.|
|10||Lifespan||T Cells have a longer lifespan.||B Cells have a shorter lifespan.|
|Absence of Surface|
Immunoglobulin in T Cells
|Presence of Surface|
Immunoglobulin in B Cell.
|12||Proliferation||Upon antigenic stimulation, differentiate into effector and|
|Upon antigenic stimulation,|
proliferate and differentiate into
plasma and memory cells.
|13||Types and their|
|T Lymphocytes are transformed|
into four types.
1) Helper T cells or Inducer
T Cells: Necessary for
the B Cell activation by
and t-effector cells.
2) Suppressor T cells:
Blocks induction and
activation of T H cells
and B cells.
3) Cytotoxic T cells or
Killer T cells: Differentiate into a CTL that lyses cells recognized as non-self.
4) Memory T Cells.
|The B Lymphocytes are modified|
into two types.
1) Plasma cells: A cell arising
from a B cell that
2) Memory cells: A long-lived
cell responsible for the anamnestic response.
|14||Secretory Product||The secretory product of the T cell is cytokines.||The secretory product of the B cell|
|15||Distribution||Widely distributed in the blood, lymph, and lymphoid tissues.||They are concentrated in the spleen, lymph nodes, bone marrow, and other lymphoid tissues.|
|T cells do not bind to the soluble antigen.||B cells are bound to the soluble antigen.|
|Mostly proteins, but some glycolipids presented on MHC|
|1) Antigens processed|
internally and presented as linear peptides bound
to MHC molecules.
2) Involves three partners: T cell receptor, antigen,
and MHC molecules.
|1) Accessible areas of protein structure containing|
sequential amino acids and non-sequential amino acids.
2) Immunoglobulin receptors bind to antigen in native
|19||Chemotaxis||T Cells have the ability to move|
to the site of infection.
|B Cells do not have the ability to|
move to the site of infection.
|20||Blood ratio||T Cells cells constitute 80% of total blood lymphocytes are.||The B-Cells constitute 20% of the total blood lymphocytes.|
|21||Immunity against||T cells defend against pathogens like viruses, protists, and|
fungi that enter the cells in the body.
|B cells fight against bacteria and|
viruses that occur in the bloodstream or lymph.
|T cells have low-affinity binding|
of self, MHC and self-peptide in the thymus are necessary for positive selection.
|B cells are true for the minority B-1|
B cell subset.
|T cells do not recognize MHC-|
|B cells can identify the MHC- presented peptides.|
|24||Allelic exclusion||T cells display more than one TCR alpha chain.||It has light (k/lambda) or TCR alpha chain.|