T lymphocytes and B lymphocytes are both white blood cells involved in the fight against infections in our bodies.
They provide immunity and also help to prevent future infections.
Differences between T cells and B cells
Sl.No | Characteristics | T Cells | B Cells |
---|---|---|---|
1 | Alternative names | They are also called T Lymphocytes. | They are also called as B Lymphocytes |
2 | Role in Immunity | T Cell is responsible for the development of cellular and humoral immunity (T Cell activates B- cells) | B Cell helps in the development of humoral immunity |
3 | Source or Origin | T Cells formed in the bone marrow. But they get matured in the Thymus gland. | Whereas B cells originate and also get matured in the bone marrow |
4 | Mature cells | Mature cells occur inside the lymph nodes. | Mature cells occur outside the lymph nodes. |
5 | Processing | T cell processing occurs mostly during the period between just before birth and a few months after birth. | B cell processing in mammals takes place in the liver (during fetal life) and bone marrow (after birth). |
6 | Discovery | T Cells were found during the ingestion of the foreign particles in the body. | B lymphocytes were discovered in the Bursa of Fabricius (lymphoid organ situated near the cloacae of birds) in birds, hence the name B lymphocytes. |
7 | Mobility | T Cells are highly motile. | B Cells are less motile. |
8 | Complement Receptors | These receptors are absent in the T Cells. | The complement receptors are present in the B Cells. |
9 | Types of Receptors | T Cell only bears TCR receptors | B Cells only bear BCR receptors. |
10 | Lifespan | T Cells have a longer lifespan. | B Cells have a shorter lifespan. |
11 | Surface Immunoglobulins | Absence of Surface Immunoglobulin in T Cells | Presence of Surface Immunoglobulin in B Cell. |
12 | Proliferation | Upon antigenic stimulation, differentiate into effector and memory cells. | Upon antigenic stimulation, proliferate and differentiate into plasma and memory cells. |
13 | Types and their Functions | T Lymphocytes are transformed into four types. 1) Helper T cells or Inducer T Cells: Necessary for the B Cell activation by T-dependent antigens and t-effector cells. 2) Suppressor T cells: Blocks induction and activation of T H cells and B cells. 3) Cytotoxic T cells or Killer T cells: Differentiate into a CTL that lyses cells recognized as non-self. 4) Memory T Cells. | The B Lymphocytes are modified into two types. 1) Plasma cells: A cell arising from a B cell that manufactures specific antibodies. 2) Memory cells: A long-lived cell responsible for the anamnestic response. |
14 | Secretory Product | The secretory product of the T cell is cytokines. | The secretory product of the B cell is antibodies. |
15 | Distribution | Widely distributed in the blood, lymph, and lymphoid tissues. | They are concentrated in the spleen, lymph nodes, bone marrow, and other lymphoid tissues. |
16 | Binds soluble antigen | T cells do not bind to the soluble antigen. | B cells are bound to the soluble antigen. |
17 | Biochemistry of the antigens | Mostly proteins, but some glycolipids presented on MHC molecules. | Proteins, glycolipids, polysaccharides. |
18 | Antigen recognition | 1) Antigens processed internally and presented as linear peptides bound to MHC molecules. 2) Involves three partners: T cell receptor, antigen, and MHC molecules. | 1) Accessible areas of protein structure containing sequential amino acids and non-sequential amino acids. 2) Immunoglobulin receptors bind to antigens in native conformation. |
19 | Chemotaxis | T Cells have the ability to move to the site of infection. | B Cells do not have the ability to move to the site of infection. |
20 | Blood ratio | T Cells cells constitute 80% of total blood lymphocytes are. | The B-Cells constitute 20% of the total blood lymphocytes. |
21 | Immunity against | T cells defend against pathogens like viruses, protists, and fungi that enter the cells in the body. | B cells fight against bacteria and viruses that occur in the bloodstream or lymph. |
22 | Recognition of self components | T cells have low-affinity binding of self, MHC, and self-peptide in the thymus are necessary for positive selection. | B cells are true for the minority B-1 B cell subset. |
23 | Recognition of MHC | T cells do not recognize MHC- presented peptides. | B cells can identify the MHC- presented peptides. |
24 | Allelic exclusion | T cells display more than one TCR alpha chain. | It has light (k/lambda) or TCR alpha chain. |