Systemic enzymes are those which are present in almost all the regions of the body.
Unlike, the localized enzymes related to the digestive system or liver metabolism, these enzymes are present in every region of the body.
Systemic enzymes examples
- Alcohol dehydrogenase
- cyclo-oxygenase (COX)
Plasmin: This is a protease enzyme that destroys clots in the blood. This keeps clot away and avoids chances of stroke due to blood flow blockage. This enzyme is released as plasminogen from the liver into the blood which converts to an active form of an enzyme called plasmin.
Ceruloplasmin is an enzyme in the plasma of blood which holds copper ions. If this enzyme does not hold calcium, it can lead to an imbalance in homeostasis. Similarly, if this enzyme is overloaded with calcium, it loses zinc and again leads to disorder.
Alcohol dehydrogenase is an enzyme which converts alcohol to an aldehyde. This enzyme helps to break down of alcohol in the body. This enzyme is good as it destroys alcohol and relives from the kick the drink gives. However, this same enzyme has to be inhibited in case of methanol poisoning.
Prostaglandin synthase: This an enzyme which synthesizes many prostaglandins from cell membranes by use of arachidonic acid.
Cyclooxygenase synthase: Also called as COX enzymes. These are of two types as COX-I and COX-II. COX-I is a constitutional enzyme while COX-II is an inductive enzyme. They are also involved in the formation of different prostaglandins. Hence, when aspirin like painkiller drugs are given. They inhibit COX enzyme and prevent further inflammation and pain. This inhibition sometimes has an untoward effect and leads to gastric pain.