Enzymes, as we know, are the biocatalysts which enhance the rate of reaction.
They have a diverse role in the body as they are involved in the process of most biochemical reactions.
There are many types of enzymes like those which help in the breakdown, synthesis, reduction, oxidation, hydration, etc.
So their function is involved in all the 12 body systems in some or other way.
Function of Enzymes
Enzymes are involved in critical body functions like
3. Blood pressure control
4. Excretion in kidney
5. Blood clotting
6. Nervous system control
7. Repair and wound healing
Digestion: Enzymes are the key molecules which process the digestion in the body. Amylase breaks down carbohydrates; proteases break down protein and lipases break down lipids. Due to this breakdown, they are easily absorbed into the bloodstream.
Metabolism: Metabolism is the important process to remove toxic waste from our body. When we consume so many foods and beverage items, they are broken down and excreted in urine or another route.
This breakdown is done by many enzymes in the liver. The liver is the major organ where most of the function occurs due to many enzymes. It is only organ with the highest number of enzymes and its dysfunction can be easily diagnosed by blood enzyme tests. Enzymes play a key role in metabolism.
Blood pressure control: The pressure of blood in the vessels is to some extent controlled by hormone angiotensin from the renin-angiotensin system. This is converted from angiotensin-1 to angiotensin-11 by an enzyme angiotensin converting enzyme. Inhibition of this enzyme helps decrease the blood pressure in high blood pressure patients.
Excretion in the kidney: Excretion through kidney is done by nephron. Nephron filters the blood and also the loop of it secretes few substances. Some enzymes are present on the nephron which prevent excretion of useful substances like aminoacids, polysaccharides, by breaking them and help in reabsorption. Ex: y-Glutamyl transpeptidase, leucine aminopeptidase, cysteine aminopeptidase, etc.
Also, carbonic anhydrase is the major enzyme which helps in excretion of acid and reabsorption of bicarbonate.
There is also sodium-potassium ATPase enzyme which helps to regulate sodium and potassium levels in the body.
Blood clotting: Clotting is a protective feature to prevent loss of blood in case of injury. Thrombin is the enzyme which activates clotting factors and enables coagulation. It specifically converts fibrinogen to fibrin thereby forming insoluble clot strands.
Nervous system control: Nervous system regulates the whole body and physiology. Neurotransmitters are the substances which help in the process. These neurotransmitters once released would help in nerve conduction and other functions. Their action is terminated once they are broken down by enzymes. For example, neurotransmitter acetylcholine acts on nicotinic receptors and is broken down by acetylcholine esterase enzyme. If it is not broken there would be persistent effects like seen in pesticide poisoning.
Repair and wound healing: Proteolytic enzymes are also involved in wound healing process. They help to breakdown the necrotic debris of tissue and enhance new cell formation leading to wound healing.
Reproduction: Sperm is a part of the male reproductive system. The male gamete unites with the ova in the uterus. This sperm when released travels through the uterine tissue and reaches the ova.
An enzyme namely hyaluronidase is released from the sperm tip (acronym) and this helps in tearing and penetration of sperm through the tissue to reach the ova. Without this enzyme, it would not be possible for the sperm to reach ova and fertilize. Sperm lives in the female reproductive tract for a span of 48 hours once released from man.
Respiration: Enzymes are also helpful in the physiology of respiration. There is an enzyme namely carbonic anhydrase in the red blood cells. This enzyme helps to convert carbon-dioxide to carbonic acid and bicarbonate ions.
Secretion: Enzymes are also responsible for few secretions in the body. For example, an enzyme called Proton potassium ATPase enzyme is involved in the secretion of gastric acid (HCl) in the stomach which aids in digestion. In case of acidity, physicians prescribe drugs which can arrest this enzyme and thereby inhibit acid secretion leading to decrease in acidity.